Saving a Sequence
When you save, the sequence is saved in the location you selected when you created the sequence or the location from which you opened it.
To save a sequence, do one of the following:

Click the Save button in the Sequence Timeline toolbar.

Click the turn-down arrow to the right of the Save button and select Save.

With focus in the Sequence Timeline area, press Ctrl+S
If you try to close a modified sequence without saving it, the Save Changes dialog box opens and asks if you want to save your changes.